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1

Haloacetamidine-Based Inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence that General Acid Catalysis Promotes Efficient Inactivation

Bryan Knuckley, Corey P. Causey, Perry J. Pellechia, Paul F. Cook, Paul R. Thompson

Journal:

Year:

2010

Language:

english

File:

PDF, 288 KB

english, 2010

2

Characterization and inactivation of an agmatine deiminase from Helicobacter pylori

Justin E. Jones, Corey P. Causey, Leslie Lovelace, Bryan Knuckley, Heather Flick, Lukasz Lebioda, Paul R. Thompson

Journal:

Bioorganic Chemistry

Year:

2010

Language:

english

File:

PDF, 922 KB

english, 2010

3

Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors

Bryan Knuckley, Yuan Luo, Paul R. Thompson

Journal:

Bioorganic & Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 302 KB

english, 2008

4

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

Nishant Dwivedi, Jagriti Upadhyay, Indira Neeli, Salar Khan, Debendra Pattanaik, Linda Myers, Kyriakos A. Kirou, Bernhard Hellmich, Bryan Knuckley, Paul R. Thompson, Mary K. Crow, Ted R. Mikuls, Elena

Journal:

Arthritis & Rheumatism

Year:

2012

Language:

english

File:

PDF, 722 KB

english, 2012

5

Ibotenic acid lesions to ventrolateral thalamic nuclei disrupts trace and delay eyeblink conditioning in rabbits

B.B. Oswald, B. Knuckley, S.A. Maddox, D.A. Powell

Journal:

Behavioural Brain Research

Year:

2007

Language:

english

File:

PDF, 595 KB

english, 2007

6

Prefrontal control of trace eyeblink conditioning in rabbits (Oryctolagus cuniculus) II: Effects of type of unconditioned stimulus (airpuff vs. periorbital shock) and unconditioned stimulus intensity

Barbara B. Oswald, Bryan Knuckley, Kathleen Mahan, Clara Sanders, Donald A. Powell

Journal:

Physiology & Behavior

Year:

2009

Language:

english

File:

PDF, 788 KB

english, 2009

7

Activity-Based Protein Profiling Reagents for Protein Arginine Deiminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe

Luo, Yuan, Knuckley, Bryan, Bhatia, Monica, Pellechia, Perry J., Thompson, Paul R.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 77 KB

english, 2006

8

The Development of N-α -(2-Carboxyl)benzoyl- N 5 -(2-fluoro-1-iminoethyl)- l -ornithine Amide ( o -F-amidine) and N-α -(2-Carboxyl)benzoyl- N 5 -(2-chloro-1-iminoethyl)- l -ornithine Amide ( o -Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors

Causey, Corey P., Jones, Justin E., Slack, Jessica L., Kamei, Daisuke, Jones, Larry E., Subramanian, Venkataraman, Knuckley, Bryan, Ebrahimi, Pedram, Chumanevich, Alexander A., Luo, Yuan, Hashimoto, H

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 4.73 MB

english, 2011

9

Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates

Lewallen, Daniel M., Steckler, Caitlin J., Knuckley, Bryan, Chalmers, Michael J., Thompson, Paul R.

Journal:

Molecular BioSystems

Year:

2012

Language:

english

File:

PDF, 1.33 MB

english, 2012

10

Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization †,‡

Luo, Yuan, Arita, Kyouhei, Bhatia, Monica, Knuckley, Bryan, Lee, Young-Ho, Stallcup, Michael R., Sato, Mamoru, Thompson, Paul R.

Journal:

Year:

2006

Language:

english

File:

PDF, 330 KB

english, 2006

11

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism †

Knuckley, Bryan, Bhatia, Monica, Thompson, Paul R.

Journal:

Year:

2007

Language:

english

File:

PDF, 329 KB

english, 2007

12

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases

Thomson, Andrew, O’Connor, Sean, Knuckley, Bryan, Causey, Corey P.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 914 KB

english, 2014

13

Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

Knuckley, Bryan, Causey, Corey P., Jones, Justin E., Bhatia, Monica, Dreyton, Christina J., Osborne, Tanesha C., Takahara, Hidenari, Thompson, Paul R.

Journal:

Year:

2010

Language:

english

File:

PDF, 3.72 MB

english, 2010

14

Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-Assisted Mechanism

Dreyton, Christina J., Knuckley, Bryan, Jones, Justin E., Lewallen, Daniel M., Thompson, Paul R.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.15 MB

english, 2014

15

Correction to The Development of N-α -(2-Carboxyl)benzoyl- N 5 -(2-fluoro-1-iminoethyl)- l -ornithine Amide ( o -F-amidine) and N-α -(2-Carboxyl)benzoyl- N 5 -(2-chloro-1-iminoethyl)- l -ornithine Amide ( o -Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors

Causey, Corey P., Jones, Justin E., Slack, Jessica L., Kamei, Daisuke, Jones, Larry E., Subramanian, Venkataraman, Knuckley, Bryan, Ebrahimi, Pedram, Chumanevich, Alexander A., Luo, Yuan, Hashimoto, H

Journal:

Journal of Medicinal Chemistry

Year:

2011

File:

PDF, 67 KB

2011

16

A Fluoroacetamidine-Based Inactivator of Protein Arginine Deiminase 4: Design, Synthesis, and in Vitro and in Vivo Evaluation

Luo, Yuan, Knuckley, Bryan, Lee, Young-Ho, Stallcup, Michael R., Thompson, Paul R.

Journal:

Journal of the American Chemical Society

Year:

2006

Language:

english

File:

PDF, 51 KB

english, 2006

17

A fluopol-ABPP HTS assay to identify PAD inhibitors

Knuckley, Bryan, Jones, Justin E., Bachovchin, Daniel A., Slack, Jessica, Causey, Corey P., Brown, Steven J., Rosen, Hugh, Cravatt, Benjamin F., Thompson, Paul R.

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

18

N- -Benzoyl-N5-(2-Chloro-1-Iminoethyl)-L-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

Willis, V. C., Gizinski, A. M., Banda, N. K., Causey, C. P., Knuckley, B., Cordova, K. N., Luo, Y., Levitt, B., Glogowska, M., Chandra, P., Kulik, L., Robinson, W. H., Arend, W. P., Thompson, P. R., H

Journal:

The Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 942 KB

english, 2011

19

Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases

Marchenko, Mikhail, Thomson, Andrew, Ellis, Terri N., Knuckley, Bryan, Causey, Corey P.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

20

Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes

Nguyen, Hao C., Wang, Min, Salsburg, Andrew, Knuckley, Bryan

Journal:

ACS Combinatorial Science

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

21

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

Chumanevich, A. A., Causey, C. P., Knuckley, B. A., Jones, J. E., Poudyal, D., Chumanevich, A. P., Davis, T., Matesic, L. E., Thompson, P. R., Hofseth, L. J.

Journal:

AJP Gastrointestinal and Liver Physiology

Year:

2011

Language:

english

File:

PDF, 2.08 MB

english, 2011

22

Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product

James, Elle D., Knuckley, Bryan, Alqahtani, Norah, Porwal, Suheel, Ban, Jisun, Karty, Jonathan A., Viswanathan, Rajesh, Lane, Amy L.

Journal:

ACS Synthetic Biology

Year:

2015

Language:

english

File:

PDF, 3.22 MB

english, 2015

23

Mechanistic studies of the agmatine deiminase from Listeria monocytogenes

Soares, C. A., Knuckley, B.

Journal:

Biochemical Journal

Year:

2016

Language:

english

File:

PDF, 800 KB

english, 2016

24

Prefrontal control of trace versus delay eyeblink conditioning: Role of the unconditioned stimulus in rabbits (Oryctolagus cuniculus).

Oswald, Barbara, Knuckley, Bryan, Mahan, Kathleen, Sanders, Clara, Powell, D. A.

Journal:

Behavioral Neuroscience

Year:

2006

Language:

english

File:

PDF, 1.02 MB

english, 2006

25

The development and characterization of a chemical probe targeting PRMT1 over PRMT5

Mann, Sarah A., Salsburg, Andrew, Causey, Corey P., Knuckley, Bryan

Journal:

Bioorganic & Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 575 KB

english, 2018